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Target Contacts Based on Their Email Domain
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Objective
Some email service providers tend to have stricter spam filters than others. You can target those contacts separately with different content to ensure better deliverability. Below is an example of a segment that excludes contacts who use Gmail from the sendout.
Segment
In this example, we show the criterion in combination with other criteria to demonstrate it with additional context. However, to achieve the objective, we only need the last condition - Email Domain Does Not Contain: @gmail.

Show detailed configuration
Conditions 1-4 are shown in this example.
Condition 5
Use Contact Profile > Profile Attribute. Select Email Domain - Does Not Contain: @gmail.
Follow-up Action
Apply this segment to any sendout targeting recipients with different content based on their domain.